Des Moines vs Sioux City: Pharmacist Salary (2026)
Compare pharmacist salaries between Des Moines, IA and Sioux City, IA. All figures are 2026 estimates projected from BLS 2025 data.
Side-by-Side Comparison
| Metric | Des Moines, IA | Sioux City, IA |
|---|---|---|
| Median Salary | $143,692▲ | $142,155 |
| Hourly Rate | $69.08▲ | $68.35 |
| Entry Level (P10) | $125,770▲ | $110,058 |
| 25th Percentile | $132,756▲ | $131,697 |
| 75th Percentile | $165,545▲ | $161,961 |
| Top Earner (P90) | $167,918▲ | $166,675 |
| Total Employed | 850▲ | 120 |
Verdict
Des Moines, IA offers better overall compensation for pharmacists, winning 4 out of 4 metrics compared to Sioux City.
The salary gap between Des Moines and Sioux City is $1,537 (1.08%). Des Moines's median is +0.14% compared to the US national median of $143,489.
Salary Range Comparison
The full salary range (10th to 90th percentile) in Des Moines spans $42,148,Sioux City spans $56,617. Sioux City has a wider pay range, suggesting more variation in pay between entry-level and experienced pharmacists.
Cost-of-Living Adjusted Comparison
After cost-of-living adjustment, Sioux City ($164,428 effective) pays 4.93% more than Des Moines ($156,696 effective).
Cost-of-living adjustment: salary × (100 / CoL index). Index of 100 = national average.
Which City Is Right for You?
Choose Des Moines if…
- ✓Higher median salary ($143,692/year)
- ✓Better top-earner potential ($167,918)
- ✓Larger job market (850 employed)
- ✓You prefer the Iowa area and lifestyle
Choose Sioux City if…
- ✓Better purchasing power (CoL-adjusted: $164,428)
- ✓You prefer the Iowa area and lifestyle
Historical Salary Growth Comparison
Based on BLS OEWS metropolitan area data, pharmacist salaries in Des Moines grew 18.2% from 2019 to 2025, compared to 13.5% growth in Sioux City over the same period.
Des Moines, IA
$119,350 (2019) → $141,110 (2025)
Sioux City, IA
$123,000 (2019) → $139,600 (2025)
View Full Salary Data
Des Moines, IA
Sioux City, IA
Frequently Asked Questions
Which city pays pharmacists more: Des Moines or Sioux City?
What is the hourly rate difference between Des Moines and Sioux City?
Should I relocate from Des Moines to Sioux City as a pharmacist?
What do entry-level pharmacists earn in Des Moines vs Sioux City?
Written by Sofia Chen, PharmD
Career Analyst
Sofia Chen has 10 years of experience in community pharmacy. She specializes in medication therapy management.
Methodology & Data Source
All salary figures are 2026 projections based on BLS OEWS May 2025 data. A 1.83% CAGR (derived from 6-year national BLS trends) was applied to estimate current compensation. Cost-of-living adjustments use BEA Regional Price Parity data. Actual salaries vary by employer, certifications, and experience.
Data Sources & Methodology
Source: BLS, OEWS , released .
Compiled and verified by Sofia Chen, PharmD, a licensed pharmacist with 10+ years of clinical experience. · View source data at BLS.gov