San Francisco vs Santa Ana: Pharmacist Salary (2026)
Compare pharmacist salaries between San Francisco, CA and Santa Ana, CA. All figures are 2026 estimates projected from BLS 2025 data.
Side-by-Side Comparison
| Metric | San Francisco, CA | Santa Ana, CA |
|---|---|---|
| Median Salary | $180,657▲ | $175,346 |
| Hourly Rate | $86.85▲ | $84.31 |
| Entry Level (P10) | $138,061▲ | $113,856 |
| 25th Percentile | $167,571▲ | $153,036 |
| 75th Percentile | $224,148▲ | $205,286 |
| Top Earner (P90) | $233,415▲ | $223,746 |
| Total Employed | 3,670▲ | 69 |
Verdict
San Francisco, CA offers better overall compensation for pharmacists, winning 4 out of 4 metrics compared to Santa Ana.
The salary gap between San Francisco and Santa Ana is $5,311 (3.03%). San Francisco's median is +25.90% compared to the US national median of $143,489.
Salary Range Comparison
The full salary range (10th to 90th percentile) in San Francisco spans $95,354,Santa Ana spans $109,890. Santa Ana has a wider pay range, suggesting more variation in pay between entry-level and experienced pharmacists.
Cost-of-Living Adjusted Comparison
After cost-of-living adjustment, San Francisco ($156,260 effective) pays 0.79% more than Santa Ana ($155,036 effective).
Cost-of-living adjustment: salary × (100 / CoL index). Index of 100 = national average.
Which City Is Right for You?
Choose San Francisco if…
- ✓Higher median salary ($180,657/year)
- ✓Better top-earner potential ($233,415)
- ✓Larger job market (3,670 employed)
- ✓Better purchasing power (CoL-adjusted: $156,260)
- ✓You prefer the California area and lifestyle
Choose Santa Ana if…
- ✓You prefer the California area and lifestyle
Historical Salary Growth Comparison
Based on BLS OEWS metropolitan area data, pharmacist salaries in San Francisco grew 15.3% from 2019 to 2025, compared to -8.5% growth in Santa Ana over the same period.
San Francisco, CA
$153,870 (2019) → $177,410 (2025)
Santa Ana, CA
$188,138 (2024) → $172,195 (2025)
View Full Salary Data
San Francisco, CA
Santa Ana, CA
Frequently Asked Questions
Which city pays pharmacists more: San Francisco or Santa Ana?
What is the hourly rate difference between San Francisco and Santa Ana?
Should I relocate from San Francisco to Santa Ana as a pharmacist?
What do entry-level pharmacists earn in San Francisco vs Santa Ana?
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Written by Sofia Chen, PharmD
Career Analyst
Sofia Chen has 10 years of experience in community pharmacy. She specializes in medication therapy management.
Methodology & Data Source
All salary figures are 2026 projections based on BLS OEWS May 2025 data. A 1.83% CAGR (derived from 6-year national BLS trends) was applied to estimate current compensation. Cost-of-living adjustments use BEA Regional Price Parity data. Actual salaries vary by employer, certifications, and experience.
Data Sources & Methodology
Source: BLS, OEWS , released .
Compiled and verified by Sofia Chen, PharmD, a licensed pharmacist with 10+ years of clinical experience. · View source data at BLS.gov