Springfield vs St. Charles: Pharmacist Salary (2026)
Compare pharmacist salaries between Springfield, MO and St. Charles, MO. All figures are 2026 estimates projected from BLS 2025 data.
Side-by-Side Comparison
| Metric | Springfield, MO | St. Charles, MO |
|---|---|---|
| Median Salary | $137,460 | $140,821▲ |
| Hourly Rate | $66.09 | $67.71▲ |
| Entry Level (P10) | $81,159 | $98,930▲ |
| 25th Percentile | $130,933▲ | $128,021 |
| 75th Percentile | $160,616▲ | $160,000 |
| Top Earner (P90) | $164,710 | $169,467▲ |
| Total Employed | 560▲ | 16 |
Verdict
St. Charles, MO offers better overall compensation for pharmacists, winning 3 out of 4 metrics compared to Springfield.
The salary gap between Springfield and St. Charles is $3,361 (2.45%). St. Charles's median is -1.86% compared to the US national median of $143,489.
Salary Range Comparison
The full salary range (10th to 90th percentile) in Springfield spans $83,551,St. Charles spans $70,537. Springfield has a wider pay range, meaning more potential for high earners but also more variation.
Cost-of-Living Adjusted Comparison
After cost-of-living adjustment, St. Charles ($157,166 effective) pays 1.28% more than Springfield ($155,173 effective).
Cost-of-living adjustment: salary × (100 / CoL index). Index of 100 = national average.
Which City Is Right for You?
Choose Springfield if…
- ✓Larger job market (560 employed)
- ✓You prefer the Missouri area and lifestyle
Choose St. Charles if…
- ✓Higher median salary ($140,821/year)
- ✓Better top-earner potential ($169,467)
- ✓Better purchasing power (CoL-adjusted: $157,166)
- ✓You prefer the Missouri area and lifestyle
Historical Salary Growth Comparison
Based on BLS OEWS metropolitan area data, pharmacist salaries in Springfield grew -0.2% from 2019 to 2025, compared to 19.2% growth in St. Charles over the same period.
Springfield, MO
$135,320 (2019) → $134,990 (2025)
St. Charles, MO
$115,971 (2024) → $138,290 (2025)
View Full Salary Data
Springfield, MO
St. Charles, MO
Frequently Asked Questions
Which city pays pharmacists more: Springfield or St. Charles?
What is the hourly rate difference between Springfield and St. Charles?
Should I relocate from Springfield to St. Charles as a pharmacist?
What do entry-level pharmacists earn in Springfield vs St. Charles?
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Written by Sofia Chen, PharmD
Career Analyst
Sofia Chen has 10 years of experience in community pharmacy. She specializes in medication therapy management.
Methodology & Data Source
All salary figures are 2026 projections based on BLS OEWS May 2025 data. A 1.83% CAGR (derived from 6-year national BLS trends) was applied to estimate current compensation. Cost-of-living adjustments use BEA Regional Price Parity data. Actual salaries vary by employer, certifications, and experience.
Data Sources & Methodology
Source: BLS, OEWS , released .
Compiled and verified by Sofia Chen, PharmD, a licensed pharmacist with 10+ years of clinical experience. · View source data at BLS.gov