Pharmacist Salary in Sioux Falls, SD: $151,044 (2026)
Quick Answer:A full-time pharmacist in Sioux Falls, SD earns a median $151,044/year (≈ $72.61/hour) in nominal terms for 2026 — projected from BLS OEWS 2025 (SOC 29-1051). Once you factor in Sioux Falls's price level (9% below national, BEA RPP 90.6), that paycheck buys what $166,658 would nationally. Nominal pay sits 13.4% above the South Dakota state average.
Official BLS data · View source
In 2026, the pharmacist salary in Sioux Falls, South Dakota, is projected to reach a median of $151,044, offering a competitive edge over the national median of $143,489. The salary range reflects the diversity of pharmacist roles, with the bottom 10% earning $125,964 and the top 90% making as much as $177,255. These figures, derived from 2025 BLS OEWS data projected into 2026, illustrate the potential earnings disparity based on the pharmacist's practice setting. Hospital clinical specialists generally command higher salaries compared to retail pharmacists, including pharmacy-in-charge (PIC) positions, highlighting the importance of specialization and experience in determining compensation in the local job market.
Salary Breakdown
| Percentile | Annual | Hourly |
|---|---|---|
| Entry Level (P10) | $125,964 | $60.56 |
| Lower Range (P25) | $138,163 | $66.42 |
| Median (P50)(typical) | $151,044 | $72.61 |
| Upper Range (P75) | $165,749 | $79.69 |
| Top Earners (P90) | $177,255 | $85.22 |
Median Salary Position
5.27% above the national average
2026 Salary Percentile Distribution in Sioux Falls
In Sioux Falls, SD, the pharmacist salary spread from the 10th to 90th percentile is $51,291 (2026 est.). At $151,044, the local median is 5.27% above the national median of $143,489.
Salary Calculator
At 40 hours/week in Sioux Falls: You'd be in the lower-middle range
How Sioux Falls Pharmacist Pay Compares
Sioux Falls median: $151,044/year (2026)
| Compared To | Median Salary | Sioux Falls Pays |
|---|---|---|
| South Dakota Average | $133,196 | +13.40% more |
| National Average | $143,489 | +5.27% more |
Pharmacists in Sioux Falls, SD earn a median of $151,044 per year (2026 est.), which is 5.27% higher than the national median of $143,489 and 13.40% above the South Dakota state average of $133,196.
Cost-of-Living Adjusted Salary
Sioux Falls has a cost of living 9.37% below the national average, meaning your salary goes further here.
Adjusted salary = nominal × (100 / CoL index). CoL index: 100 = national average.
Sioux Falls, SD has a cost-of-living index of 90.631 (below the national average of 100). A pharmacist earning $151,044 nominally has purchasing power equivalent to $166,658 in an average-cost city — an effective 10.34% boost.
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2019 BLS Actual
$119,250
2025 BLS Actual
$148,330
2026 Current Est.
$151,044
2019–2027 Growth
+29.0%
Salary Trajectory for Pharmacists in Sioux Falls (2019–2027)
2019–2025: actual BLS OEWS data for this metro area. 2026+: CAGR 1.83% projection.
| Year | Annual Salary | Status |
|---|---|---|
| 2019 | $119,250 | Actual |
| 2020 | $122,890 | Actual |
| 2021 | $128,190 | Actual |
| 2022 | $136,830 | Actual |
| 2023 | $140,950 | Actual |
| 2024 | $143,000 | Actual |
| 2025 | $148,330 | Actual |
| 2026(current) | $151,044 | Estimated |
| 2027 | $153,809 | Projected |
Based on 7 years of BLS OEWS data for the Sioux Falls metropolitan area, the median pharmacist salary grew 24.4% from $119,250 (2019) to $148,330 (2025). At a 1.83% compound annual growth rate, salaries are projected to reach $153,809 by 2027 — a total increase of $34,559 (28.98%) from 2019.
Note: Historical values (2019–2025) are actual BLS OEWS figures for the Sioux Falls metropolitan area, sourced from annual Occupational Employment and Wage Statistics surveys. 2026–2026 figures are current estimates, and 2027 values are projections, calculated using a 1.83% CAGR derived from 7-year BLS historical data. Actual salaries may vary based on employer, experience, certifications, and local market conditions.
Salary by Experience Level
| Experience | Estimated Salary Range |
|---|---|
| 0-2 years (New Graduate) | $125,964 – $138,163 |
| 3-5 years (Mid Career) | $138,163 – $151,044 |
| 5+ years (Experienced) | $151,044 – $165,749 |
| 10+ years (Top Earner) | $165,749 – $177,255 |
PharmD salary ranges estimated from BLS percentile data. Individual pharmacist compensation varies by employer, certifications, and specialization.
Pharmacist Job Market in Sioux Falls
With 690 pharmacists currently employed in the Sioux Falls area, the local job market is robust, especially given the lower cost of living index of 90.631. This index translates to a relative affordability that significantly impacts take-home purchasing power, enhancing the attractiveness of pharmacist pay in Sioux Falls SD. Among employers, hospital inpatient pharmacies and specialty pharmacies tend to offer the highest salaries, particularly for roles requiring board certification or residency training. Additionally, the pay disparity is driven by factors such as shift differentials, certification stipends, and the ongoing consolidation in the retail pharmacy sector, which has led to variability in pay structures. To maximize earning potential, pharmacists should consider pursuing additional certifications through organizations like BPS and seek opportunities in high-paying sectors, while staying aware of the evolving landscape in retail and clinical services.
More salary data for Sioux Falls, SD:
Frequently Asked Questions
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Written by Sofia Chen, PharmD
Career Analyst
Sofia Chen has 10 years of experience in community pharmacy. She specializes in medication therapy management.
Methodology & Data Source
Salary figures on this page are 2026 projections based on the Bureau of Labor Statistics Occupational Employment and Wage Statistics (OEWS) survey, May 2026 release. The BLS reported a median annual salary of $148,330 for pharmacistsin the Sioux Falls metropolitan area. A 1.83% compound annual growth rate (CAGR), calculated from 6-year national BLS wage trends, was applied to project current 2026 compensation. Percentile ranges (P10–P90) represent the full salary distribution across experience levels and practice settings in this market.
Data Sources & Methodology
Source: BLS, OEWS, 7-year dataset (–). Per-city data from annual BLS metropolitan area surveys.
2026 figures are projected from 2025 BLS data using a compound annual growth rate (CAGR) of 1.83%, derived from historical BLS wage trends for pharmacists (SOC 29-1051).
Compiled and verified by Sofia Chen, PharmD, a licensed pharmacist with 10+ years of clinical experience. · View source data at BLS.gov