Sioux Falls vs Yankton: Pharmacist Salary (2026)
Compare pharmacist salaries between Sioux Falls, SD and Yankton, SD. All figures are 2026 estimates projected from BLS 2025 data.
Side-by-Side Comparison
| Metric | Sioux Falls, SD | Yankton, SD |
|---|---|---|
| Median Salary | $151,044▲ | $127,996 |
| Hourly Rate | $72.61▲ | $61.54 |
| Entry Level (P10) | $125,964▲ | $95,921 |
| 25th Percentile | $138,163▲ | $120,208 |
| 75th Percentile | $165,749▲ | $140,987 |
| Top Earner (P90) | $177,255▲ | $145,389 |
| Total Employed | 690▲ | 4 |
Verdict
Sioux Falls, SD offers better overall compensation for pharmacists, winning 4 out of 4 metrics compared to Yankton.
The salary gap between Sioux Falls and Yankton is $23,048 (18.01%). Sioux Falls's median is +5.27% compared to the US national median of $143,489.
Salary Range Comparison
The full salary range (10th to 90th percentile) in Sioux Falls spans $51,291,Yankton spans $49,468. Sioux Falls has a wider pay range, meaning more potential for high earners but also more variation.
Cost-of-Living Adjusted Comparison
After cost-of-living adjustment, Sioux Falls ($166,658 effective) pays 20.83% more than Yankton ($137,927 effective).
Cost-of-living adjustment: salary × (100 / CoL index). Index of 100 = national average.
Which City Is Right for You?
Choose Sioux Falls if…
- ✓Higher median salary ($151,044/year)
- ✓Better top-earner potential ($177,255)
- ✓Larger job market (690 employed)
- ✓Better purchasing power (CoL-adjusted: $166,658)
- ✓You prefer the South Dakota area and lifestyle
Choose Yankton if…
- ✓You prefer the South Dakota area and lifestyle
Historical Salary Growth Comparison
Based on BLS OEWS metropolitan area data, pharmacist salaries in Sioux Falls grew 24.4% from 2019 to 2025, compared to 10.1% growth in Yankton over the same period.
Sioux Falls, SD
$119,250 (2019) → $148,330 (2025)
Yankton, SD
$114,180 (2024) → $125,696 (2025)
View Full Salary Data
Sioux Falls, SD
Yankton, SD
Frequently Asked Questions
Which city pays pharmacists more: Sioux Falls or Yankton?
What is the hourly rate difference between Sioux Falls and Yankton?
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Written by Sofia Chen, PharmD
Career Analyst
Sofia Chen has 10 years of experience in community pharmacy. She specializes in medication therapy management.
Methodology & Data Source
All salary figures are 2026 projections based on BLS OEWS May 2025 data. A 1.83% CAGR (derived from 6-year national BLS trends) was applied to estimate current compensation. Cost-of-living adjustments use BEA Regional Price Parity data. Actual salaries vary by employer, certifications, and experience.
Data Sources & Methodology
Source: BLS, OEWS , released .
Compiled and verified by Sofia Chen, PharmD, a licensed pharmacist with 10+ years of clinical experience. · View source data at BLS.gov